Stuffed animals may give off the illusion of fragility, but those little guys tend to go through a lot. With kids toting them around everywhere — and putting them through some inventive and strenuous playtime — stuffed animals tend to develop some wear and tear, and it may be unclear how to clean them.
Unless your stuffed animal specifically comes with machine washable tag, however, you will want to refrain from tossing it into the washing machine. This could end up in a reorganization of the stuffing, discoloration, and even ripping.
If all else fails and the stuffed animal still seems to be dirty, and you are semi-proficient with sewing, you can try and replace the stuffing. Open up a side seam and remove the stuffing. Then, for added cleanliness, use one of the methods above to clean the un-stuffed animal.